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Dr. Parthasarathy Lab
Our sleep research laboratory focuses on sleep, breathing, and inflammation in both ambulatory and critically ill patients. Our primary focus involves clinical-translational research that identifies the mechanistic underpinnings of sleep disturbances during critical illness with the goal of improving sleep and inflammation in critically ill patients. Our long-term goals are to improve patient outcomes and health-related quality of life in both ambulatory and critically ill patients by improving their sleep and breathing.
Our animal laboratory is involved in the search of the mechanisms underlying the relationship between sleep fragmentation, inflammation and cognition. We study such mechanism in a murine sleep deprivation model that utilizes transgenic mouse models.
Our clinical trials unit is involved in industry-funded trials that test novel therapies for sleep-disordered breathing in ambulatory patients and novel therapeutic strategies in critically ill patients.
Sleep intervention during Acute Lung Injury (R01 NIH/NHLBI; HL095748):
The central purpose of this proposal is to study the short-term effects of sedation with sympatholysis on sleep and inflammation in critically ill patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Clinicaltrials.gov #NCT01050699
Peer-Driven Intervention as an Alternate Model of Care Delivery and Coordination for Sleep Apnea (PiCOS; IHS-1306-2505):
The overarching goal of this study is to improve patient-centered outcomes using peer-driven intervention and an itneractive voice response system in patients with sleep apnea. Clinicaltrials.gov #NCT02056002
Chronic moderate sleep restriction in older long and older average sleepers:
The proposed clinical trial will provide the most comprehensive Phase 1 assessment of risks and benefits of chronic moderate TIB restriction ever conducted. (R01-HL095799 (MPI): Youngstedt, Parthasarathy, Irwin, Jean-Louis)
Comparative-effectiveness of CBT-I and CAM in facilitating sleep in ICU survivors (Johrei Foundation):
The primary purpose of this grant proposal is to compare CBT-I and CAM as therapies for sleep disturbances in survivors of critical illness.
Obesity and obstructive sleep apnea in hepatocellular carcinoma progression (PQA2) 1R21CA184920:
Test the effect of chronic intermittent hypoxia (IH) on the progression of fatty liver and chemically-induced hepatocellular carcinoma (HCC) in lean and diet-induced obese (DIO) mice. Also, to determine the role of HIF-1α on hepatic lipid accumulation and HCC progression in response to DIO and chronic IH.